Prevalence of Hepatitis B and Hepatitis C Virus Infection in Patients with Advanced Renal Failure: A Tertiary Care Centre Study from North Indian Population

Abstract: Viral hepatitis (Hepatitis B Virus (HBV) & Hepatitis C (HCV)) related liver disease is a leading cause of morbidity and mortality especially in the patients with advanced renal failure who are treated dialysis, this due to high number blood transfusion sessions and/or cross contamination from dialysis circuits. Aims Objectives: This study aimed determine prevalence HBV HCV infections (ARF). Materials Methods: A cross-sectional was done joint collaboration Department Nephrology Gastroenterology, KGMU, Lucknow, June 2018 2020 among, CRF patients. Clinical data such as age, gender, duration dialysis; transfusions, Serum sample collected each patient. Serological markers for were determined ELISA by using commercial diagnostic kits. HCV-RNA HBV-DNA quantitatively polymerase chain reaction (PCR) assay. Results: total 934 attended nephrology OPD. Out patients, 65 (6.96%) screened positive HBV/HCV infection. The results also showed that viral infection haemodialysis (HD) without HD 8.25% 6.3% respectively. Conclusion: It has been found infections, particularly common on HD.